Search results for "Citrullinated peptide"

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Potential involvement of IL-9 and Th9 cells in the pathogenesis of rheumatoid arthritis

2015

Objective IL-9 has been shown to be upregulated before the clinical onset of articular disease in RA. The exact role of IL-9 and Th9 cells in RA, however, has not yet been adequately studied. The aim of this study was to evaluate the expression of IL-9 and IL-9-expressing cells in RA patients. Methods IL-9, IL-9R, PU.1, IL-9, thymic stromal lymphopoietin (TSLP), IL-4 and TGF-β expression was assessed by real-time-PCR in the synovial tissues of RA and OA patients. IL-9, IL-9R, IL-4, TSLP and TGF-β were also investigated by immunohistochemistry. Peripheral CD4(+) T cell subsets were studied by flow cytometry analysis before and after incubation with citrullinated peptides. Results IL-9 was ov…

CD4-Positive T-LymphocytesMaleCitrullinated peptide; IL-9; Rheumatoid arthritis; Th9 cells; Adolescent; Adult; Arthritis Rheumatoid; CD4-Positive T-Lymphocytes; Cells Cultured; Cytokines; Female; Gene Expression Regulation; Humans; Interleukin-4; Interleukin-9; Lymphocyte Activation; Male; Middle Aged; RNA Messenger; Synovial Membrane; T-Lymphocyte Subsets; Transforming Growth Factor beta; Young Adult; Rheumatology; Medicine (all); Pharmacology (medical)MessengerLymphocyte ActivationArthritis RheumatoidT-Lymphocyte SubsetsTransforming Growth Factor betaRheumatoidTh9 cellPharmacology (medical)Cells CulturedCulturedmedicine.diagnostic_testbiologyMedicine (all)Synovial MembraneMiddle Agedmedicine.anatomical_structureCD4-Positive T-LymphocyteCytokinesFemaleArthritiHumanAdultThymic stromal lymphopoietinAdolescentT cellCD3T-Lymphocyte SubsetCitrullinated peptidePeripheral blood mononuclear cellFlow cytometryYoung AdultRheumatologyThymic Stromal LymphopoietinmedicineHumansInterleukin 9RNA MessengerCytokineInterleukin 4Rheumatoid arthritibusiness.industryInterleukin-9IL-9Settore MED/16 - ReumatologiaGene Expression RegulationImmunologybiology.proteinRNACellInterleukin-4Synovial membranebusiness
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The new criteria for classification of rheumatoid arthritis: what we need to know for clinical practice.

2011

The new criteria for classification of Rheumatoid Arthritis have been recently released. They incorporate the anti-Citrullinated Protein antibody testing and the other classic criteria in a score system (the diagnosis of definite rheumatoid arthritis is made by a total score ≥6). These criteria try to meet the pressing needs to gain sensitivity in early disease. Symptoms, elevated acute-phase response, serologic abnormality, joint involvement were all considered for scoring after confirming the presence of synovitis in at least 1 joint in the absence of an alternative diagnosis that better explains the synovitis. However, no sensitivity and specificity has been showed. Moreover, Area Under …

medicine.medical_specialtySettore MED/09 - Medicina InternaArthritisDiseasePeptides CyclicSensitivity and SpecificityArthritis RheumatoidRheumatologyInternal medicineSynovitisInternal MedicineMedicineHumansIntensive care medicineAutoantibodiesReceiver operating characteristicbusiness.industryAutoantibodymedicine.diseaseSettore MED/45 - Scienze Infermieristiche Generali Cliniche E PediatricheRheumatoid arthritis Classification criteria Anti-citrullinated peptide autoantibodies Bayesian reasoning Likelihood ratio Sensitivity and specificityRheumatologySettore MED/16 - ReumatologiaRheumatoid arthritisPhysical therapyAbnormalitybusinessBiomarkersEuropean journal of internal medicine
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